Severe infections linked to brain atrophy and dementia
“The idea that infections can influence brain health for some people has been a no-brainer, especially those who themselves experienced infections,” said Keenan Walker, a tenure-track investigator and the director of the Multimodal Imaging of Neurodegenerative Disease Unit at the National Institute on Aging.
Even small infections can change the way we think and behave. More-severe infections can, in the short term, result in delirium, which may be associated with long-term cognitive problems, Walker said. “Big infection, big immune response — not good for the brain,” he said.
he hypothesis that infections may play a role in neurodegenerative diseases has been around, albeit more on the fringes, Walker said. That changed with the coronavirus pandemic and evidence of the lasting cognitive costs of long covid, which invigorated interest in the field.
In the current study, people with a history of infections also had changes to 260 immune-related proteins out of the 942 researchers tested from blood samples. A subset of 35 proteins was also associated with brain-volume changes. Some proteins seemed pathogenic and linked to reduced brain volume, while others were protective.
In general, infections were associated with increases in pathogenic proteins and decreases in protective ones.
Website: International Conference on Infectious Diseases.
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