Saturday, April 5, 2025

Are rising lower respiratory infection hospital admissions linked to dirty air?




The Covid crisis highlighted gaps in our understanding of the role that air pollution plays in infections.

A flurry of studies carried out during and after the crisis allowed a UK government advisory group to conclude that long-term exposure to air pollution may contribute to worse coronavirus symptoms. The group offered examples that included a study of more than 3 million people in Denmark that showed air pollution added to the risk of death or hospital admission with severe Covid, especially in the least well off.


Now a study led by the Barcelona Institute for Global Health has examined whether long-term exposure to air pollution is a factor in hospital admissions for lower respiratory infections (LRIs). LRIs include chest infections, pneumonia and bronchitis and place a large and increasing burden on health services. Alone, they accounted for a 15% increase in the rate of hospital admissions in the UK between 1999 and 2019.

Prof Cathryn Tonne, who led the study, said: “We have so much evidence of the negative health effects of air pollution on a wide range of health outcomes. We were surprised to see how limited the evidence still was for air pollution and LRIs in adults.”

Nearly 4 million adults in Catalonia were studied over a five-year period. During this time, 94,000 people were admitted to hospital with LRIs – almost 60,000 of these had flu or pneumonia. Their health records were then compared with air pollution in their neighbourhoods. People over 65, and especially men with blood pressure problems, were most vulnerable to needing hospital admission with an LRI that was worsened by air pollution. This included particle pollution and exposure to nitrogen dioxide, a pollutant from diesel exhaust and burning fossil gas. Men living in the most polluted 25% of neighbourhoods had a 50% increased chance of being admitted to hospital with these infections compared with those in cleaner areas, but even here the risk was not zero.

Tonne said: “Importantly, we also observed positive associations between air pollution and hospital admission for LRI even at relatively low pollution concentrations. Continuing to reduce air pollution will have broad health benefits. This includes reducing the risk of hospital admission for common respiratory infections, particularly among vulnerable people.”

In 2022, Prof Sir Stephen Holgate chaired an inquiry by the UK Academy of Medical Sciences into the health burden from respiratory infections that the UK experiences each winter. Commenting on the study from Catalonia, Holgate said: “It is known that air pollution episodes trigger hospital admissions for serious lung infections. This study of nearly 4 million people clearly shows that long-term exposure to outdoor particulate pollution and nitrogen dioxide also drives infection-related hospital admissions.

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Website: International Conference on Infectious Diseases

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Thursday, April 3, 2025

Hormonal Contraceptives and Allergies: Is There a Link?




TOPLINE:

Among women, the use of systemic hormonal contraceptives is independently associated with an increased likelihood of having allergic rhinitis, a study showed.

METHODOLOGY:

Researchers analyzed data from 46,205 women in the United States (average age, 30.9 years) to examine associations between the use of systemic hormonal contraceptives and the risk for rhinitis, which encompasses nasal symptoms like sneezing, congestion, itching, or rhinorrhea.
Overall, 4606 participants had a diagnosis of rhinitis, of whom 92.4% had allergic rhinitis and 7.6% had nonallergic rhinitis.
Contraceptives were classified as progestin-only or estrogen-containing.

TAKEAWAY:

Participants using systemic hormonal contraceptives had 32% higher odds of having allergic rhinitis (adjusted odds ratio [aOR], 1.32; 95% CI, 1.20-1.44) than those not using systemic hormonal contraceptives, the researchers reported.
Progestin-only contraceptives (aOR, 1.29; 95% CI, 1.12-1.48) and estrogen-containing contraceptives (aOR, 1.35; 95% CI, 1.21-1.51) were associated with an increased risk for allergic rhinitis.
No significant associations were observed for nonallergic rhinitis.

IN PRACTICE:

“Clinicians may have a higher vigilance for rhinitis symptoms in adult women taking systemic hormonal contraceptives,” the study authors wrote.

SOURCE:

Richard G. Chiu, with the University of Illinois Chicago, was the corresponding author of the study, which was published online on March 21 in Laryngoscope Investigative Otolaryngology.

LIMITATIONS:

The duration of exposure to hormonal contraceptives was not always clear from medication records. The study had a cross-sectional design and did not establish a causal relationship between hormonal contraceptive use and rhinitis.

Website: International Conference on Infectious Diseases

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Tuesday, April 1, 2025

England, Wales and Northern Ireland Imported Zika Cases Reach New Highs




(Vax-Before-Travel News)

Recent data from the UK Health Security Agency (UKHSA) show that the number of imported Zika cases in England, Wales, and Northern Ireland (EWNI) increased last year.

On March 27, 2025, the UKHSA disclosed that the number of Zika virus disease cases reached 16 in England, Wales, and Northern Ireland during 2024, compared to 8 cases in 2023.

Most Zika-infected travellers returned to EWNI from South-Eastern Asia, where countries reported locally acquired infections.

For example, since 2016, the Zika virus has been reported in India's 16 different states/union territories.

Dr. Philip Veal, Consultant in Public Health at the UKHSA, stated in a media release, "It is essential to take precautions against mosquito-borne infections such as dengue while travelling abroad. Simple steps, such as using insect repellent, covering exposed skin, and sleeping under insecticide-treated bed nets, can reduce the risk of mosquito-borne infections."

Although Zika virus cases are rarely reported and don't often cause serious illness, the infection poses a significant risk to pregnant women, as it can be passed to the fetus.

An Original Investigation published by JAMA Public Health in January 2025 found that children born with congenital Zika syndrome (CZS) had a 13.10-fold higher hazard of death compared with those without CZS.

This health risk is well-known in the Region of the Americas, where Zika infections have substantially increased.

Over 42,127 ZIka cases were confirmed in the Americas in 2024, with the highest proportion of Zika cases reported in Argentina, Brazil, Bolivia, Colombia, and Costa Rica.

The U.S. CDC says Zika-spreading mosquitoes are found throughout Puerto Rico, where the Department of Health reported 16 cases in 2024.

In 2023, over 37,659 Zika cases were reported by various countries in the Americas.

As of March 31, 2025, no drug or vaccine prevents Zika virus infection. However, Zika vaccine candidates are conducting clinical trials in 2025.

Website: International Conference on Infectious Diseases

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Are rising lower respiratory infection hospital admissions linked to dirty air?

The Covid crisis highlighted gaps in our understanding of the role that air pollution plays in infections. A flurry of studies carried out d...