Biogenic Copper-Based Nanoparticles: Emerging Antimicrobial Agents Against Pathogenic Microorganisms | Nanomedicine & Infection Control #researchawards

Introduction

Biogenic copper-based nanoparticles (CuNPs) have emerged as promising antimicrobial agents due to their potent activity and environmentally sustainable synthesis routes. Green synthesis approaches utilize plants, microorganisms, and biological wastes, where phytochemicals, enzymes, and proteins act as natural reducing and stabilizing agents. These processes avoid toxic chemicals, operate under mild conditions, and yield nanoparticles typically smaller than 100 nm with bioactive surface coatings. Such features not only enhance antimicrobial performance but also align with global demands for eco-friendly nanotechnologies in healthcare, agriculture, aquaculture, and food safety.

Green Synthesis Strategies and Biological Control of Nanoparticle Properties

Biological systems play a decisive role in governing the morphology, size, crystallinity, and stability of copper-based nanoparticles. Plant extracts rich in polyphenols, flavonoids, and terpenoids enable rapid reduction and effective capping, while bacteria, fungi, and algae provide enzymatic and protein-mediated pathways for controlled nanoparticle formation. The choice of biological source, extraction method, and reaction parameters strongly influences nanoparticle uniformity, dispersibility, and long-term stability, directly impacting antimicrobial efficiency.

Antimicrobial Mechanisms of Biogenic Copper-Based Nanoparticles

The antimicrobial activity of biogenic CuNPs arises from multiple interconnected mechanisms. These include the generation of reactive oxygen species (ROS), sustained release of Cu²⁺ ions, disruption of microbial cell membranes, and interference with enzymatic, metabolic, and genetic processes. Surface-bound biomolecules from green synthesis further enhance microbial interaction and biofilm penetration, enabling broad-spectrum activity against Gram-positive and Gram-negative bacteria, fungi, and resistant microbial communities.

Monometallic versus Hybrid Copper-Based Nanoparticle Systems

While monometallic Cu and CuO nanoparticles exhibit strong antimicrobial properties, hybrid systems such as Ag–Cu, Zn–CuO, and CuS nanoparticles demonstrate enhanced efficacy through synergistic effects. These hybrids integrate redox activity, ion release, and in some cases photothermal or photocatalytic mechanisms, leading to improved microbial killing at lower doses. Comparative studies highlight the potential of hybrid systems to overcome antimicrobial resistance and expand functional applications.

Applications in Medicine, Agriculture, Aquaculture, and Food Safety

Biogenic copper-based nanoparticles have found diverse applications due to their antimicrobial versatility. In medicine, they are incorporated into wound dressings, implants, and antimicrobial coatings. In agriculture and aquaculture, they support sustainable crop protection and disease management by reducing reliance on chemical pesticides and antibiotics. In food safety and packaging, CuNPs help inhibit spoilage and pathogenic microorganisms, extending shelf life while maintaining eco-friendly standards.

Toxicity, Challenges, and Future Directions

Despite their benefits, the toxicity of biogenic CuNPs is highly context-dependent, influenced by size, shape, surface chemistry, capping agents, concentration, and exposure conditions. Poorly capped or ultra-small nanoparticles may induce cytotoxicity, hemolysis, developmental defects, or growth inhibition, whereas appropriate functionalization improves biocompatibility and selectivity. Future research must focus on standardized physicochemical characterization, harmonized toxicity testing, and mechanistic studies to enable safe translation, regulatory approval, and responsible commercialization of biogenic copper-based nanomaterials.

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